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KMID : 1161920140110010048
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Journal of Medicine and Life Science
2014 Volume.11 No. 1 p.48 ~ p.51
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The Efficacy of Recombinant Human Growth Hormone Treatment in Prepubertal Children with Short Stature due to Small for Gestational Age
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Shin Kyung-Sue
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Abstract
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Recombinant human growth hormone (GH) has been recognized as an effective treatment for short-statured children born small for their gestational age (SGA). This report described the treatment of recombinant human GH in prepubertal children with short stature due to SGA. Recombinant human GH was administered with a subcutaneous dose of 0.1 IU/kg/day(0.033 mg/kg/day) for 6 days per week. Height velocity and height standard deviationscore (SDS) were increased, and recombinant human GH was well tolerated and relatively safe. However, despite similar circumstance, there were some differences between two cases with a gained height velocity and height SDS. Although the response to GH treatment is influenced by the dose, age at start, stature at start, and means parental height, further studies are necessary to predict the efficacy of GH treatment in short-statured children born small for SGA.
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KEYWORD
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Human Growth Hormone, Small for Gestational Age
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